The Nonhematopoietic Effects of Erythropoietin in Skin Regeneration and Repair: From Basic Research to Clinical Use
Identifieur interne : 000137 ( Main/Exploration ); précédent : 000136; suivant : 000138The Nonhematopoietic Effects of Erythropoietin in Skin Regeneration and Repair: From Basic Research to Clinical Use
Auteurs : Heiko Sorg [Allemagne] ; Yves Harder [Allemagne] ; Christian Krueger [Allemagne] ; Kerstin Reimers [Allemagne] ; Peter M. Vogt [Allemagne]Source :
- Medicinal Research Reviews [ 0198-6325 ] ; 2013-05.
English descriptors
- Teeft :
- Acad, Anemic patients, Angiogenesis, Angiogenic, Angiogenic response, Antiapoptotic, Apoptosis, Apoptotic cell death, Arteriolar dilatation, Biochem biophys, Biol, Biol chem, Blood cell production, Blood vessels, Body weight, Bone marrow, Brine, Broblasts, Buemi, Capillary perfusion, Cell death, Cerami, Chronic wounds, Clin, Closure, Contaldo, Current research, Cytokine, Dermatol, Diabetic mice, Dysfunction, Endothelial, Endothelial cells, Endothelial nitric oxide synthase, Enos, Epidermal, Epor, Erbayraktar, Erythropoiesis, Erythropoietin, Erythropoietin production, Erythropoietin receptor, Flap, Flap survival, Follicle, Galeano, Gassmann, Ghezzi, Granulation, Granulation tissue, Growth factor, Hair follicles, Hannover, Healing, Healing capacity, Hematocrit, Hematocrit increase, Hypoxia, Hypoxic conditions, Inducible, Inducible nitric oxide synthase, Inos, International units, Ischemia, Ischemic, Jelkmann, Keratinocytes, Macrophage, Masuda, Matrix, Medicinal, Medicinal research reviews, Menger, Microvascular, Mrna, Nagao, Natl, Neovascularization, Nephrol, Nephrol dial transplant, Nitric, Nitric oxide, Nonhealing wounds, Nonhematopoietic, Nonhematopoietic effects, Pathway, Perfusion, Physiol, Pivotal role, Plast, Plast reconstr surg, Plastic surgery, Pleiotropic, Pleiotropic effects, Pleiotropic functions, Proc, Proc natl acad, Random perfusion, Receptor, Recombinant, Reconstr, Reconstructive, Reconstructive surgery, Regeneration, Renal, Research reviews, Rhuepo, Sasaki, Skin regeneration, Skin wound healing, Skin wounds, Sorg, Surg, Synthase, Systemic, Tissue protection, Tissue survival, Vegf, Wound closure, Wound healing, Wound repair.
Abstract
Erythropoietin (EPO) is the main regulator of red blood cell production but there exists also a variety of nonhematopoietic properties. More recent data show that EPO is also associated with the protection of tissues suffering from ischemia and reperfusion injury as well as with improved regeneration in various organ systems, in particular the skin. This review highlights the mechanisms of EPO in the different stages of wound healing and the reparative processes in the skin emphasizing pathophysiological mechanisms and potential clinical applications. There is clear evidence that EPO effectively influences all wound‐healing phases in a dose‐dependent manner. This includes inflammation, tissue, and blood vessel formation as well as the remodeling of the wound. The molecular mechanism is predominantly based on an increased expression of the endothelial and inducible nitric oxide (NO) synthase with a consecutive rapid supply of NO as well as an increased content of vascular endothelial growth factor (VEGF) in the wound. The improved understanding of the functions and regulatory mechanisms of EPO in the context of wound‐healing problems and ischemia/reperfusion injury, especially during flap surgery, may lead to new considerations of this growth hormone for its regular clinical application in patients.
Url:
DOI: 10.1002/med.21259
Affiliations:
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Rev.</title><idno type="ISSN">0198-6325</idno><idno type="eISSN">1098-1128</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-05">2013-05</date><biblScope unit="volume">33</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="637">637</biblScope><biblScope unit="page" to="664">664</biblScope></imprint><idno type="ISSN">0198-6325</idno></series><idno type="istex">457A3A1071180D46F61F16ECA4FCA3B09DCCA7CA</idno><idno type="DOI">10.1002/med.21259</idno><idno type="ArticleID">MED21259</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0198-6325</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Anemic patients</term><term>Angiogenesis</term><term>Angiogenic</term><term>Angiogenic response</term><term>Antiapoptotic</term><term>Apoptosis</term><term>Apoptotic cell death</term><term>Arteriolar dilatation</term><term>Biochem biophys</term><term>Biol</term><term>Biol chem</term><term>Blood cell production</term><term>Blood vessels</term><term>Body weight</term><term>Bone marrow</term><term>Brine</term><term>Broblasts</term><term>Buemi</term><term>Capillary perfusion</term><term>Cell death</term><term>Cerami</term><term>Chronic wounds</term><term>Clin</term><term>Closure</term><term>Contaldo</term><term>Current research</term><term>Cytokine</term><term>Dermatol</term><term>Diabetic mice</term><term>Dysfunction</term><term>Endothelial</term><term>Endothelial cells</term><term>Endothelial nitric oxide synthase</term><term>Enos</term><term>Epidermal</term><term>Epor</term><term>Erbayraktar</term><term>Erythropoiesis</term><term>Erythropoietin</term><term>Erythropoietin production</term><term>Erythropoietin receptor</term><term>Flap</term><term>Flap survival</term><term>Follicle</term><term>Galeano</term><term>Gassmann</term><term>Ghezzi</term><term>Granulation</term><term>Granulation tissue</term><term>Growth factor</term><term>Hair follicles</term><term>Hannover</term><term>Healing</term><term>Healing capacity</term><term>Hematocrit</term><term>Hematocrit increase</term><term>Hypoxia</term><term>Hypoxic conditions</term><term>Inducible</term><term>Inducible nitric oxide synthase</term><term>Inos</term><term>International units</term><term>Ischemia</term><term>Ischemic</term><term>Jelkmann</term><term>Keratinocytes</term><term>Macrophage</term><term>Masuda</term><term>Matrix</term><term>Medicinal</term><term>Medicinal research reviews</term><term>Menger</term><term>Microvascular</term><term>Mrna</term><term>Nagao</term><term>Natl</term><term>Neovascularization</term><term>Nephrol</term><term>Nephrol dial transplant</term><term>Nitric</term><term>Nitric oxide</term><term>Nonhealing wounds</term><term>Nonhematopoietic</term><term>Nonhematopoietic effects</term><term>Pathway</term><term>Perfusion</term><term>Physiol</term><term>Pivotal role</term><term>Plast</term><term>Plast reconstr surg</term><term>Plastic surgery</term><term>Pleiotropic</term><term>Pleiotropic effects</term><term>Pleiotropic functions</term><term>Proc</term><term>Proc natl acad</term><term>Random perfusion</term><term>Receptor</term><term>Recombinant</term><term>Reconstr</term><term>Reconstructive</term><term>Reconstructive surgery</term><term>Regeneration</term><term>Renal</term><term>Research reviews</term><term>Rhuepo</term><term>Sasaki</term><term>Skin regeneration</term><term>Skin wound healing</term><term>Skin wounds</term><term>Sorg</term><term>Surg</term><term>Synthase</term><term>Systemic</term><term>Tissue protection</term><term>Tissue survival</term><term>Vegf</term><term>Wound closure</term><term>Wound healing</term><term>Wound repair</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Erythropoietin (EPO) is the main regulator of red blood cell production but there exists also a variety of nonhematopoietic properties. More recent data show that EPO is also associated with the protection of tissues suffering from ischemia and reperfusion injury as well as with improved regeneration in various organ systems, in particular the skin. This review highlights the mechanisms of EPO in the different stages of wound healing and the reparative processes in the skin emphasizing pathophysiological mechanisms and potential clinical applications. There is clear evidence that EPO effectively influences all wound‐healing phases in a dose‐dependent manner. This includes inflammation, tissue, and blood vessel formation as well as the remodeling of the wound. The molecular mechanism is predominantly based on an increased expression of the endothelial and inducible nitric oxide (NO) synthase with a consecutive rapid supply of NO as well as an increased content of vascular endothelial growth factor (VEGF) in the wound. The improved understanding of the functions and regulatory mechanisms of EPO in the context of wound‐healing problems and ischemia/reperfusion injury, especially during flap surgery, may lead to new considerations of this growth hormone for its regular clinical application in patients.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Hanovre</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Sorg, Heiko" sort="Sorg, Heiko" uniqKey="Sorg H" first="Heiko" last="Sorg">Heiko Sorg</name></region><name sortKey="Harder, Yves" sort="Harder, Yves" uniqKey="Harder Y" first="Yves" last="Harder">Yves Harder</name><name sortKey="Harder, Yves" sort="Harder, Yves" uniqKey="Harder Y" first="Yves" last="Harder">Yves Harder</name><name sortKey="Krueger, Christian" sort="Krueger, Christian" uniqKey="Krueger C" first="Christian" last="Krueger">Christian Krueger</name><name sortKey="Reimers, Kerstin" sort="Reimers, Kerstin" uniqKey="Reimers K" first="Kerstin" last="Reimers">Kerstin Reimers</name><name sortKey="Sorg, Heiko" sort="Sorg, Heiko" uniqKey="Sorg H" first="Heiko" last="Sorg">Heiko Sorg</name><name sortKey="Vogt, Peter M" sort="Vogt, Peter M" uniqKey="Vogt P" first="Peter M." last="Vogt">Peter M. Vogt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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